Science DirectionsScience Directions

Life Science — Proteomics

The complex structure of proteins — their concentration, degradation and modification — is the field of Proteomics.

Proteomics is about identifying, quantifying and characterising the protein content of an organism, an organ, a subcellular fraction, or even a more purified subset of proteins.

Mass Spectrometry has become an essential tool as scientists develop understanding of disease processes, next-generation cures, diagnostic tools and natural-product based advances.

Bruker offers a wide range of solutions across multiple mass-spec technologies — from Ion Traps and Triple Quadrupoles through advanced MALDI TOF/TOF, UHR-Q-TOF and FT-ICR — delivering a full suite of tools for qualitative and quantitative protein studies. The world-renowned ProteinScape software ties together every aspect of a proteomics study across those platforms.

Bruker is driving the quest for deeper insights and taking 'omics' knowledge generation to new heights, with productivity and versatility improvements in bottom-up proteomics, glycomics, quantitative proteomics, intact protein analysis, post-translational modifications and metabolomics.

Bruker also collaborates with Professor Matthias Mann's group to add UHR-QTOF support to the state-of-the-art MaxQuant quantitative proteomics software, enabling researchers to use the full potential of mass-spectrometry-driven proteomics in multi-OMICS approaches.

We have been using the Impact for almost a year for routine shot-gun bottom-up proteomics. In combination with the CaptiveSpray nanoBooster, the instrument has provided an excellent level of sustainable performance, capable of delivering untouched performance for over 6–8 weeks of 24/7 use.

Professor Alain Van Dorsselaer, LSMBO, Strasbourg